Separation anxiety in dogs manifests as distress and anxiety specifically when they are separated from their owners or family. Key signs and symptoms include reactionary behaviors not typical for the dog, such as destructive chewing, destroying household items, or having accidents indoors (urinating or defecating). Other indications can be excessive barking, howling, or whining, pacing, trembling, drooling, or excessive panting. Changes in behavior when owners are present, like constantly following them around the house or a decreased appetite, can also point to separation anxiety.